Table 1.

Properties of an ideal anti-orthopoxvirus drug

Active against vaccinia, monkeypox and variola virus

Should be active orally for ease of administration

Long intracellular half-life is desirable so dosing can be infrequent

Must be stable for long periods under adverse storage conditions

Needs to be inexpensive, so large amounts can be stockpiled

Must have a tolerable safety profile also for children and immunocompromised individuals