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(A) Schematic representation of the fulllength FADD and Caspase-8. (B-C) Sequence alignments and secondary structures of FADD DED and Caspase-8 DEDs (DED1 and DED2) are shown. (D) Co-expression of FADD DED and Caspase-8 DEDs is shown by SDS-PAGE. Elution profile of the oligomeric DED complex is shown. (E) Gel-filtrations of FADD DED and Caspase-8 DEDs mutants are shown.
