Screening conditions for regiodivergent tandem reaction^a.

Entry	[Pd]	L	Acid	x	Yieldb (%)	rrc
1	Pd(PPh3)4	—	A1	20	75	52 : 48
2	Pd(PPh3)4	—	A2	20	65	63 : 37
3	Pd(PPh3)4	—	A3	20	60	54 : 46
4	Pd(PPh3)4	—	A1	50	90	75 : 25
5	Pd(PPh3)4	—	A1	100	91	94 : 6
6	Pd(OAc)2	PPh3	A1	20	48	60 : 40
7	[Pd(allyl)Cl]2	PPh3	A1	20	36	67 : 33
8	Pd(allyl)Cp	PPh3	A1	20	71	13 : 87
9	Pd(allyl)Cp	PPh3	A2	20	80	40 : 60
10	Pd(allyl)Cp	PPh3	A3	20	82	8 : 92
11	Pd(allyl)Cp	PPh3	A4	20	47	24 : 76
12	Pd(allyl)Cp	PPh3	A5	20	Trace	—
13	Pd(allyl)Cp	PPh3	A3	100	62	44 : 56
14d	Pd(PPh3)4	—	A1	100	87	96 : 4
15d	Pd(allyl)Cp	PPh3	A3	20	73	30 : 70
16e	Pd(PPh3)4	—	A2	40	80	95 : 5

^aUnless noted otherwise, reactions were performed with 1,6-enyne 5b (0.1 mmol), imine 3a (0.05 mmol), [Pd] source (10 mol%), L (20 mol%), acid (x mol%) and 4 Å MS (20 mg) in degassed dry toluene (0.5 mL) at 70 °C for 12 h under Ar.

^bIsolated yield.

^crr = 7a : 8a, determined by ¹H-NMR analysis.

^dWith 5c (0.1 mmol) instead of 5b.

^eWith 1b (0.1 mmol) and 2a (0.1 mmol) instead of 5b at 80 °C.