Fig. 1.

Easy Vax™ vaccine delivery system. The Easy Vax™ vaccine delivery system has two parts: an electrically conductive microneedle array coated with dried vaccine DNA and an Easy Vax™ device designed to insert the array into skin and to provide the electrical pulses to deliver DNA into cells. The Easy Vax™ device contains a battery powered pulse generator capable of delivering pulses up to 120 volts. The microneedle arrays used in this study have 80 needles arranged in an 8 × 10 matrix with a 0.6 mm distance tip to tip within and between rows of needles (see inset). Depth of insertion was set by adjusting a collar surrounding the needle array and by adjusting the force and speed of array insertion with a spring adjustment. The average insertion depth of needles in this study was 0.45 mm.