Figure 3.

Correlation between the cytotoxic effects of γδ T cells and ligand expression on patient GBM tumor PDG cells. Correlations were analyzed between the cytotoxicity of γδ T cells toward PDG cells at a 20:1 E:T ratio and the ligand expression of the patient GBM cell lines. The ligands were grouped according to the receptors they bind to. PVR (black circle) and Nectin-2 (white circle) were grouped as DNAM-1 ligands (left panel) while MICA (black circle) and ULBP2/5/6 (white circle) were grouped as NKG2D ligands (right panel). Experiments were done with GBM tumor cells PDG cells from 10 patients and γδ T cells from 5 healthy donors and cytotoxicity assays were done as triplicates. Data were analyzed by Pearson’s correlation.