Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 9;18(11):2711–2730. doi: 10.1080/15548627.2022.2047344

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Informa UK Limited, trading as Taylor & Francis Group

PMC Copyright notice

Figure 6. — Activation of RTN4-S1PR2 and vascular autophagic activation, as well as angiogenesis in the ipsilateral thalamus after cortical infarction. (A) Immunoblotting shows the expression of S1PR2, RHOA, and ROCK1 in vessels of the ipsilateral thalamus in the IgG-Fc and RTN4-Δ20-Fc groups at 7 days after MCAO. (B-D) Quantitative analysis of S1PR2, RHOA and ROCK1 levels relative to TUBA. n = 4, data are expressed as median ± interquartile range. *P < 0.05, compared with the IgG-Fc group. (E) Immunoblotting shows the expression of MAP1LC3B-II, BECN1 and SQSTM1 in vessels of the ipsilateral thalamus in the IgG-Fc and RTN4-Δ20-Fc groups at 7 days after MCAO. (F-H) Quantitative analysis of MAP1LC3B-II, BECN1 and SQSTM1 levles relative to GAPDH. n = 4, data are expressed as median ± interquartile range. *P < 0.05, compared with the IgG-Fc group. (I) Co-staining for BrdU (green) and LAMA1 (red) within the ipsilateral thalamus in the IgG-Fc and RTN4-Δ20-Fc group at 7 days after MCAO (arrows). Scale bar: 50 μm, 100 μm. (J and K) Quantitative analysis of BrdU⁺_LAMA1⁺ cells and vessel density. n = 6, data are expressed as median ± interquartile range. **P < 0.01, compared with the IgG-Fc group.