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. 2022 Oct 31;54(1):3069–3078. doi: 10.1080/07853890.2022.2138530

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© 2022 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — RNA-seq shows ncRNA may be dysregulated in CSF from ALS patients. (A) Workflow of the experiment from sample to sequencing data. (B) Summary of the number of aligned reads that were annotated and the ncRNA species they aligned to. (C) MA plots of ncRNA dysregulation in slow- (ALS-SP) and fast-progression (ALS-FP) ALS patients compared to healthy controls, and ALS-FP compared to ALS-SP. Dots in red were significantly dysregulated compared to healthy control (horizontal dotted line representing p < 0.05).