Table A1:
Diagnostic accuracy of symptoms in detecting individuals that subsequently require hospitalization
| Symptom | % (95% CI) | |||
|---|---|---|---|---|
| SN | SP | NPV | PPV | |
| Any symptom | 96.2 (80.4% to 99.9%) | 14.7 (12.1% to 17.7%) | 99.0 (93.2% to 99.9%) | 4.4 (4.0% to 4.7%) |
| Fatigue | 73.1 (52.2% to 88.4%) | 51.0 (47.1% to 54.9%) | 97.9 (96.1% to 98.9%) | 5.7 (4.5% to 7.1%) |
| Cough | 73.1 (52.2% to 88.4%) | 53.2 (49.2% to 57.1%) | 98.0 (96.3% to 98.9%) | 5.9 (4.7% to 7.5%) |
| Headache | 30.8 (14.3% to 51.8%) | 59.8 (56.0% to 63.7%) | 95.5 (94.3% to 96.5%) | 3.0 (1.7% to 5.3%) |
| Myalgias | 46.2 (26.6% to 66.6%) | 63.4 (59.6% to 67.1%) | 96.7 (95.3% to 97.7%) | 4.8 (3.2% to 7.2%) |
| Fever | 69.2 (48.2% to 85.7%) | 67.8 (64.0% to 71.4%) | 98.2 (96.8% to 99.0%) | 8.0 (6.1% to 10.3%) |
| Rhinorrhea | 11.5 (2.5% to 30.2%) | 67.8 (64.0% to 71.4%) | 95.0 (94.2% to 95.7%) | 1.4 (0.5% to 4.0%) |
| Pharyngitis | 26.9 (11.6% to 47.8%) | 70.4 (66.7% to 73.9%) | 96.0 (95.0% to 96.8%) | 3.5 (1.9% to 6.5%) |
| Dysguesia | 11.5 (2.5% to 30.2%) | 69.8 (66.1% to 73.3%) | 95.1 (94.4% to 95.8%) | 1.5 (0.5% to 4.3%) |
| Anosmia | 15.4 (4.4% to 34.9%) | 72.6 (68.9% to 76.0%) | 95.5 (94.7% to 96.2%) | 2.2 (0.9% to 5.3%) |
| Chills | 53.9 (33.4% to 73.4%) | 75.4 (71.8% to 78.6%) | 97.6 (96.4% to 98.4%) | 8.1 (5.7% to 11.4%) |
| Anorexia | 38.5 (20.2% to 59.4%) | 77.2 (73.8% to 80.4%) | 96.9 (95.8% to 97.7%) | 6.4 (3.9% to 10.1%) |
| Diarrhea | 38.5 (20.2% to 59.4%) | 84.7 (81.6% to 87.4%) | 97.2 (96.2% to 97.9%) | 9.2 (5.7% to 14.5%) |
| Arthralgias | 34.6 (17.2% to 55.7%) | 86.8 (84.0% to 89.3%) | 97.1 (96.1% to 97.8%) | 9.6 (5.7% to 15.7%) |
| Depression or anxiety | 19.2 (6.6% to 39.4%) | 87.3 (84.5% to 89.8%) | 96.4 (95.7% to 97.0%) | 5.8 (2.6% to 12.1%) |
| Nausea or vomiting | 19.2 (6.6% to 39.4%) | 87.9 (85.1% to 90.3%) | 96.4 (95.7% to 97.0%) | 6.0 (2.8% to 12.7%) |
| Chest pain | 15.4 (4.4% to 34.9%) | 88.4 (85.6% to 90.7%) | 96.3 (95.6% to 96.8%) | 5.1 (2.2% to 11.9%) |
| Dyspnea | 26.9 (11.6% to 47.8%) | 89.8 (87.2% to 92.0%) | 96.8 (96.0% to 97.5%) | 9.6 (5.1% to 17.2%) |
| Insomnia | 23.1 (9.0% to 43.7%) | 90.1 (87.5% to 92.3%) | 96.7 (95.9% to 97.3%) | 8.6 (4.3% to 16.4%) |
| Sputum production | 34.6 (17.2% to 55.7%) | 91.2 (88.7% to 93.2%) | 97.2 (96.3% to 97.9%) | 13.6 (8.1% to 22.1%) |
| Abdominal pain | 7.7 (1.0% to 25.1%) | 92.1 (89.7% to 94.1%) | 96.1 (95.7% to 96.5%) | 3.8 (1.0% to 13.2%) |
| Conjunctivitis | 15.4 (4.4% to 34.9%) | 94.1 (92.0% to 95.8%) | 96.5 (95.9% to 97.0%) | 9.5 (3.9% to 21.4%) |
| Otalgia | 3.9 (0.1% to 19.6%) | 95.2 (93.3% to 96.7%) | 96.1 (95.8% to 96.4%) | 3.1 (0.5% to 18.5%) |
| Wheezing | 3.9 (0.1 % to 19.6%) | 97.5 (96.0% to 98.6%) | 96.2 (95.9% to 96.5%) | 5.9 (0.9% to 31.2%) |
| Confusion | 11.5 (2.5% to 30.2%) | 98.8 (97.6% to 99.5%) | 96.5 (96.0% to 97.0%) | 27.3 (9.6% to 57.1%) |
SN = Sensitivity; SP = Specificity; NPV = Negative predictive value; PPV = Positive predictive value