Table 4.

Cost of migraine-specific agents used in the treatment of acute migraines.37,38

Drug	Usual adult treatment dose	Cost for one full dosea (US$)
Triptans (serotonin 5-HT1B, 1D receptor agonists)
Almotriptan	12.5 mg PO as a single dose	42
Eletriptan (Relpax®)	40 mg PO as a single dose	61
Frovatriptan (Frova®)	2.5 mg PO as a single dose	72
Naratriptan (Amerge®)	2.5 mg PO as a single dose	25–29
Sumatriptan (Imitrex®, Onzetra® Xsail®, Sumavel DosePro®, Tosymra®, Zembrace® SymTouch®)	50–100 mg PO as a single dose	25
	6 mg SQ as a single dose	15–85
	One 20 mg spray as a single dose in one nostril	49–81
	11 mg (powder, breath-activated) insufflated in each nostril	141
Rizatripan (Maxalt®)	5–10 mg PO as a single dose	6–36
Zolmitriptan (Zomig®)	2.5 mg PO as a single dose	1–55
	One (2.5–5 mg) spray as a single dose in one nostril	106–111
Ergot derivative
Dihydroergotamine (DHE 45®, Migranal®, Trudhesa®)	1 mg IV as a single dose	150–199
	1 mg IM as a single dose
	1 mg SQ as a single dose
	One (0.5 mg or 0.75 mg) spray into each nostril repeat in 15 minutes (4 sprays/dose)	66–514
Ditan (serotonin 5-HT1F receptor agonist)
Lasmiditan (Reyvow®)	50–100 mg PO as a single dose	106
Gepants (calcitonin gene-related peptide (CGRP) receptor antagonists)
Rimegepant (Nurtec®)	75 mg PO as a single dose	138
Ubrogepant (Ubrelvy®)	50–100 mg PO as a single dose	112

^aCost is based on the average wholesale price (AWP) at the usual adult treatment dose rounded to the nearest dollar. The lowest AWP noted in Red Book Online is provided for generic products.

IM, intramuscular; IV, intravenous; PO, by mouth; SQ, subcutaneous.