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. 2022 Nov 2;24(Suppl 6):S42–S51. doi: 10.1093/neuonc/noac208

Table 1.

Clinical Trials for New and Recurrent High-grade Glioma

Study System Patients (n) Pretreatment Tumor Volume Treatment Time Tumor Volume Ablated (%) Imaging Modality Complications
Sugiyama et al.21 Nd:YAG 5 1.2–3 cm 30-40 min NR CCTS NR
Bettag et al.67 Nd:YAG 5 1–3.5 cm NR NR CT, MRI NR
Sakai et al.68 Nd:YAG 5 NR NR 100% in 4/5 patients CCTS None
Kahn et al.20 Nd:YAG 8 1.8–3.4 cm 10 min 15–87% CT None
Schwabe et al.19 Nd:YAG 18 2–3.5 cm 2–23 min NR MRI NR
Reimer et al.69 Nd:YAG 4 1–3.5 cm 3–13 min NR MRI Hemorrhage
Leonardi et al.70 Nd:YAG 24 2.1–3.3 cm NR NR MRI Neurological deficit
Leonardi and Lumenta71 Nd:YAG 24 2.1–3.3 cm NR NR MRI Neurological deficit
Schwarzmaier et al.22 Nd:YAG 16 21.6 ± 18.6 cm3 NR NR MRI None
Jethwa et al.24 Viusalase 20 0.37–68.9 cm3 1.83–35.9 min NR MRI Hemicraniectomy from edema
Hawasli et al.72 NeuroBlate 17 14.1 ± 10.7 cm3 3.11–10.32 h 8.5–67.7 cm3 (45), 6.2–47.3 (52) MRI Transient neurological deficit, DVT, meningitis, hyponatremia
Sloan et al.62 NeuroBlate 10 2.6–19 cm3 7.5–50.2 min 2.6–19.01 cm3 MRI Vascular injury, neurological deficits
Mohammadi et al.61 NeuroBlate 34 0.7–49.9 cm3 NR 91%–98% MRI Neurological deficit, DVT, hyponatremia, wound infection
Leuthardt et al.58 NeuroBlate 19 <3 cm diameter NR NR MRI None
Rennert et al.73 NeuroBlate 38 NR NR NR MRI NR
de Groot et al.30 NeuroBlate 89 7.7–8.5 NR 91%–99% MRI Neurological deficit, DVT

Abbreviations: CCTS, computer-controlled temperature system; CT, computed tomography; MRI, magnetic resonance imaging; Nd:YAG; neodymium-doped yttrium aluminum garnet; NR, not recorded; DVT, deep vein thrombosis.