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. 2022 May 31;28(6):890–909. doi: 10.1093/humupd/dmac027

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© The Author(s) 2022. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (https://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 3. — BCL6 may affect stemness and differentiation of trophoblast stem/progenitor cells. (A) Potential functions of BCL6 in vCTBs. BCL6 may promote vCTB proliferation, inhibit differentiation and fusion of vCTBs into the STB, and possibly affect stemness and lineage commitment of trophoblast stem/progenitor cells. (B) Potential functions of BCL6 in trophoblasts within the cell column. BCL6 may facilitate proliferation of vCTBs, and affect differentiation of vCTBs into iEVTs and artEVTs. artEVT, endoarterial EVT; dCCT, distant cell column trophoblast; EVT, extravillous trophoblast; GC, giant cell; iEVT, interstitial EVT; MФ, macrophage; pCCT, proximal cell column trophoblast; SA, spiral artery; STB, syncytiotrophoblast; vCTB, villous cytotrophoblast; vMSC, villous mesenchymal stromal cell; uNK, uterine natural killer.