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. 2022 Nov 2;17(11):e0276976. doi: 10.1371/journal.pone.0276976

Table 2. Univariate analysis of factors associated with skeletal muscle mass index (SMI) in male.

All Young-old (aged 60–74) Old-old (aged 75≤)
n = 152 n = 90 n = 62
Variables r p-value r p-value r p-value
Age -0.363 <0.001 -0.228 0.031 -0.317 0.012
BMI 0.677 <0.001 0.752 <0.001 0.589 <0.001
BFP 0.033 0.685 0.203 0.055 -0.015 0.909
HbA1c -0.180 0.026 -0.047 0.659 -0.453 <0.001
Total protein -0.073 0.372 -0.171 0.107 0.057 0.662
Albumin 0.092 0.274 -0.094 0.383 0.224 0.100
T-bilirubin 0.088 0.280 -0.096 0.371 0.318 0.012
ID-bilirubin 0.133 0.111 -0.093 0.389 0.383 0.004
Hypertension 0.101 0.215 0.175 0.099 0.147 0.254
Hyperlipidemia -0.105 0.200 -0.108 0.309 -0.087 0.504
CAD -0.259 0.001 -0.097 0.365 -0.322 0.011
CVD -0.062 0.449 -0.029 0.787 -0.008 0.950
Albuminuria 0.003 0.975 -0.057 0.605 0.153 0.240
Renal failure 0.079 0.333 -0.010 0.923 0.246 0.054
DDP4i -0.006 0.940 -0.060 0.573 0.020 0.875
SGLT2i 0.140 0.085 0.148 0.165 -0.031 0.814
SU -0.144 0.076 0.009 0.936 -0.278 0.029
Metformin 0.108 0.187 0.130 0.222 -0.036 0.783
GLP-1RA -0.106 0.194 -0.038 0.721 -0.180 0.161
Insulin -0.103 0.206 -0.120 0.259 -0.027 0.836

Spearman rank correlation test was performed to evaluate the correlation between skeletal muscle mass index

(SMI) and various variables.

Number of patients with missing data: Albumin, all n = 8, young-old n = 1, old-old n = 7; ID-Bil, all n = 8, young-old n = 1, old-old n = 7; Albuminuria, all n = 5, young-old n = 4, old-old n = 1.

Abbreviation: BMI, body mass index; SMI, skeletal muscle mass index; BFP, body fat percent; HbA1c, hemoglobin A1c; T-bilirubin, total bilirubin; ID-bilirubin, indirect bilirubin; CAD, cardiovascular disease; CVD, cerebrovascular disease; DPP4i, dipeptidyl peptidase-4 inhibitor; SGLT2i, sodium glucose co transporter-2 inhibitor; SU, sulfonylurea; GLP1-RA, glucagon-like peptide-1 receptor agonists.