Table 1. Demographic and clinical data of convalescents after liver transplantation.
OLT (n = 24) | |||||
Sex | male (n;%) | 13; 54.2 | |||
Time after transplantation in years | median (min; max) | 4.5 (1;28) | |||
Underlying liver disease | |||||
Hereditary | n; % | 7; 29 | |||
Autoimmune liver disease | n; % | 6; 25 | |||
Viral hepatitis | n; % | 5; 21 | |||
Acute liver failure | n; % | 2; 8.3 | |||
Cryptic cirrhosis | n; % | 2; 8.3 | |||
Metabolic liver disease | n; % | 2; 8.3 | |||
Immunosuppression at diagnosis of COVID-19 | |||||
Steroids | yes n (%) | 9; 27.5 | |||
Tacrolimus | low n (%) | 6; 25 | |||
high n (%) | 15; 62.5 | ||||
no Tac n (%) | 3; 12.5 | ||||
CsA | yes n (%) | 3; 12.5 | |||
CNI | yes n (%) | 24; 100 | |||
MMF | yes n (%) | 18; 75 | |||
MMF dose in mg/day | median (min; max) | 500 (0; 1500) | |||
Everolimus | yes n (%) | 3; 12.5 | |||
Aza | yes n (%) | 1; 4.2 | |||
Aza dose in mg/day | 50 | ||||
Sirolimus | yes n (%) | 1; 4.2 | |||
IS score | 1 | 1; 4.2 | |||
2 | 8; 33.3 | ||||
3 | 6; 25 | ||||
4 | 6; 25 | ||||
5 | 2; 8 | ||||
6 | 1; 4.2 | ||||
Reduction immunosuppression during COVID-19 | yes (n;%) | 4; 16.6 | |||
Symptoms during infection (multiple answers possible) | |||||
None | n; % | 2; 13.3 | |||
Cough/dyspnea | n; % | 9; 60 | |||
Fatigue | n; % | 5; 30 | |||
Fever | n; % | 4; 26.7 | |||
Body aches | n; % | 3; 20 | |||
Headache | n; % | 2; 13.3 | |||
Score throat | n; % | 2; 13.3 | |||
Sweat | n; % | 1; 6.7 | |||
Sniffles | n; % | 1; 6.7 | |||
WHO clinical progression scale | |||||
1 | 7 | ||||
2 | 14 | ||||
3 | 1 | ||||
4 | 2 | ||||
Hospitalization during COVID-19 | yes (n;%) | 4; 16.6 | |||
1–2 months | 3–4 months | ≥ 5 months non-vacc. | ≥ 5 months vacc. | ||
n = 15 | n = 16 | n = 3 | n = 14 | ||
Sex | male (n;%) | 9; 60 | 9; 56.3 | 2; 66.7 | 8; 57.1 |
Age | median (min; max) | 56 (25;68) | 56 (22;72) | 56 (20;68) | 56 (32; 72) |
Time after diagnosis in weeks | median (min; max) | 6 (3;8) | 15 (9;20) | 26 (25; 30) | 29 (24;56) |
Symptoms (multiple answers possible) | |||||
None | n; % | 3; 20 | 10; 62.5 | 3; 100 | 11; 78.6 |
Cough/dyspnea | n; % | 4; 26.7 | 3, 18.8 | 0; 0 | 1; 12.8 |
Fatigue | n; % | 6; 40 | 2; 12.5 | 0; 0 | 2; 14.3 |
Fever | n; % | 1; 6.7 | 0; 0 | 0; 0 | 0; 0 |
Body aches | n; % | 1; 6.7 | 0; 0 | 0; 0 | 0; 0 |
Headache | n; % | 1; 6.7 | 0; 0 | 0; 0 | 0; 0 |
Score throat | n; % | 3; 20 | 2; 12.5 | 0; 0 | 0; 0 |
Sweat | n; % | 0; 0 | 0; 0 | 0; 0 | 0; 0 |
Sniffles | n; % | 1; 6.7 | 0; 0 | 0; 0 | 0; 0 |
AST | median (min; max) | 25 (8;180) | 26 (15;100) | 20 (13;22) | 26 (16;68) |
ALT | median (min; max) | 28 (10;308) | 25 (5;86) | 15 (12;21) | 22 (4;82) |
GGT | median (min; max) | 32 (11;1353) | 32 (5;487) | 19 (18;86) | 26 (7;584) |
AP | median (min; max) | 104 (58;564) | 92 (60;470) | 99 (60;110) | 98 (5;630) |
Bili | median (min; max) | 9 (5;74) | 13 (5;23) | 6 (4;10) | 12 (7;118) |
IgG | median (min; max) | 10.37 (7.7; 22.35) | 10.54 (6.02; 18.61) | 10.95 (10.95; 10.95) | 10.41 (9.5; 18.85) |