Table 2. Description of the parameter values.
| Parameter | Nominal | Units | References |
|---|---|---|---|
| k1 | 7.5 × 10−6 | 1/(Molecules⋅min) | Fitted |
| k2 | 1.32 | 1/(Molecules⋅min) | Fitted |
| k3 | 1.75 × 10−5 | 1/(Molecules⋅min) | Fitted |
| k4 | 1.34 × 10−5 | 1/(Molecules⋅min) | Fitted |
| k5 | 1.0 | 1/min | Fitted |
| k6 | 2.26 | 1/min | Fitted |
| k7 | 9.88 × 10−4 | 1/(Molecules⋅min) | Fitted |
| k8 | 7.59 × 10−4 | 1/(Molecules⋅min) | Fitted |
| k9 | 8.7 × 10−1 | 1/min | Fitted |
| k10 | 2.63 × 10−4 | 1/(Molecules⋅min) | Fitted |
| k11.1 | 2.2 × 10−1 | 1/min | Fitted |
| k11.2 | 2.5 × 10−1 | 1/min | Fitted |
| ⋆k12 | 1.25 × 10−3 | 1/(Molecules⋅min) | Fitted |
| ⋆k13.1 | 2.25 × 10−3 | 1/min | Fitted |
| ⋆k13.2 | 2.0 | 1/min | Fitted |
| ⋆k14 | 9.97 × 10−4 | 1/(Molecules⋅min) | Fitted |
| ⋆k15.1 | 1.49 | 1/min | Fitted |
| ⋆k15.2 | 107.5 | 1/min | Fitted |
| ⋆k16 | 6.1 × 10−4 | 1/(Molecules⋅min) | Fitted |
| ⋆k17.1 | 1.95 | 1/min | Fitted |
| ⋆k17.2 | 22.8 | 1/min | Fitted |
| ⋆k18 | 7.0 × 10−4 | 1/(Molecules⋅min) | Fitted |
| ⋆k19.1 | 8.71 × 10−1 | 1/min | Fitted |
| k ⋆k19.2 | 10.6 | 1/min | Fitted |
| ‡k20 | 3.28 × 10−1 | 1/min | [69] |
| ‡k21 | 1.47 × 10−1 | 1/min | [69] |
| ‡k22 | 1.34 × 10−2 | 1/min | [69] |
| ‡k23 | 1.4 × 10−2 | 1/min | [69] |
| k24 | 8.76 × 10−1 | 1/min | Fitted |
| k25 | 4.89 | 1/min | Fitted |
| k26 | 1.38 | 1/min | Fitted |
| k27 | 1.04 × 10−1 | 1/min | Fitted |
| k28 | 1.39 × 10−2 | 1/min | [70] |
| k29 | 4.36 × 10−2 | 1/min | [70] |
| k30 | 2.38 × 10−3 | 1/min | [70] |
| k31 | 7.37 × 10−3 | 1/min | [70] |
| †k32 | 8.64 × 10−1 | 1/min | [71] |
| †k33 | 6.26 × 10−1 | 1/min | [71] |
| †k34 | 1.52 | 1/min | [71] |
| †k35 | 4.02 | 1/min | [71] |
| k36 | 1.73 × 10−1 | 1/min | Fitted |
| k37 | 2.5 × 10−2 | 1/min | [72] |
| k38 | 3.51 × 10−4 | 1/min | [4] |
| k39 | 1.95 × 10−3 | 1/min | [73, 74] |
| k40 | 1.85 × 10−2 | 1/min | [72] |
| k41 | 1.18 × 10−2 | 1/min | Fitted |
| k42 | 5.09 × 10−3 | 1/min | Fitted |
| k43 | 1.43 × 10−2 | 1/min | Fitted |
| k44 | 5.05 × 10−4 | 1/(Molecules⋅min) | Fitted |
| k45 | 2.94 × 10−3 | 1/min | Fitted |
| k46 | 1.2 × 10−3 | 1/min | [56, 75] |
| k47 | 4.77 × 10−2 | 1/min | Fitted |
⋆ Transcription factor dissociation rates for STAT2-IRF9 were assumed to be substantially higher than for ISGF3, while the association rates were assumed to be identical [5].
† Translations rates were assumed to be close to reported averages times ≈ 16 Proteins/mRNA/min [71].
‡ Transcription rates were assumed to be close to reported averages times to produce a mRNA ≈ 20 min [69].