Table 2.

Statistical outcomes from overall analyses. Values in bold-face font met statistical significance at p<0.05

Dose-Response Determinations of Single Drugs: Main Effects of Dose
Drug	Scratch	Facial Rub	Species-Typical	Passive Visual	Lip Droop	Rest/Sleep Posture
Oxycodone mu-opioid agonist	F(4,12)=18.3, p<0.05	F(4,12)=4.8, p<0.05	F(4,12)=4.0, p<0.05	F(4,120)=0.3, p=0.87	Zero instances, ANOVA not conducted	Zero instances, ANOVA not conducted
U50–488H prototypical KOR agonist	F(3,9)=4.9, p<0.05	F(3,9)=5.9, p<0.05	F(3,9)=2.5, p=0.13	F(3,9)=2.3, p=0.15	F(3,9)=4.8, p<0.05	F(3,9)=3.0, p=0.09
Nalfurafine biased KOR agonist	F(3,9)=2.2, p=0.15	F(3,9)=2.2, p=0.15	F(3,9)=5.3, p<0.05	F(3,9)=3.3, p=0.07	F(3,9)=2.8, p=0.10	F(3,9)=8.4, p<0.05
Triazole 1.1 biased KOR agonist	F(3,9)=3.0, p=0.09	F(3,9)=0.8, p=0.55	F(3,9)=7.6, p<0.05	F(3,9)=1.4, p=0.31	F(3,9)=1.0, p=0.44	F(3,9)=0.9, p=0.48