Table 3.

Statistical outcomes from overall analyses. Values in bold-face font met statistical significance at p<0.05

Dose-Response Determinations of Drug Mixtures: Main Effects Oxycodone (first) or KOR Agonist (second) Dose
Drug	Scratch	Facial Rub	Species-Typical	Passive Visual	Lip Droop	Rest/Sleep Posture
Oxycodone + U50–488H	F(3,9)=12.4, p<0.05 F(3,9)=83.8, p<0.05	F(3,9)=5.1, p<0.05 F(3,9)=3.0, p=0.09	F(3,9)=1.7, p=0.24 F(3,9)=8.2, p<0.05	F(3,9)=0.9, p=0.48 F(3,9)=8.7, p<0.05	F(3,9)=1.1, p=0.38 F(3,9)=35.4, p<0.05	F(3,9)=0.04, p=0.99 F(3,9)=6.7, p<0.05
Oxycodone + Nalfurafine	F(3,9)=14.6, p<0.05 F(3,9)=47.0, p<0.05	F(3,9)=3.7, p=0.06 F(3,9)=2.3, p=0.14	F(3,9)=3.0, p=0.09 F(3,9)=14.6, p<0.05	F(3,9)=0.4, p=0.78 F(3,9)=19.8, p<0.05	F(3,9)=1.6, p=0.25 F(3,9)=10.4, p<0.05	F(3,9)=0.3, p=0.99 F(3,9)=4.4, p<0.05
Oxycodone + Triazole 1.1	F(3,9)=20.4, p<0.05 F(3,9)=32.8, p<0.05	F(3,9)=8.4, p<0.05 F(3,9)=1.4, p=0.31	F(3,9)=1.7, p=0.24 F(3,9)=10.3, p<0.05	F(3,9)=0.3, p=0.80 F(3,9)=12.9, p<0.05	F(3,9)=1.3, p=0.34 F(3,9)=1.2, p=0.35	F(3,9)=0.4, p=0.76 F(3,9)=0.8, p=0.54