Fig. 3. High-confidence protein-protein interactions of TOP2A and TOP2B.

Known protein-protein interactions were retrieved from the BioGRID database (v4.4.205) and the recent studies (75, 86, 130). Interactions were filtered to only include interactions detected in at least two independent studies or experimental approaches. Orange nodes indicate known cancer driver genes (from COSMIC Cancer Gene Census database), red circles highlight human transcription factors [from (156)], and cancer patient survival–associated markers are shown in bold [data from The Cancer Genome Atlas (TCGA)].