Table 1.

Examples of single-cell microgels previously demonstrated.

Material	Encapsulated cell type	Functionalization	Crosslinking method	Targeted application	Ref.
Alginate	MSC,a) OP9,b) HUVECc)	RGD peptides	Ionic, CaCO3 NPs on cell surface	Therapeutic	[46]
	NIH3T3,d) MSC, HUVEC	RGD peptides	Ionic, Ca2+ freed by acidification	Research	[49]
	PCC 6803,e) CC-4532,f) MC3T3-E1g)	N/A	Ionic (CLEX)h)	Research & Therapeutic	[38]
	HCT116i)	N/A	Ionic, droplet merging	Research & Diagnostic	[130]
Agarose	CEMj) & K562k) CRL-2265	N/A	Temperature	Research	[66]
	GM09947,l) GM09948m)	Reverse primers	Temperature	Research & Diagnostic	[64]
	MSC	Fibronectin & fibrinogen	Temperature	Therapeutic	[67]
Dextran	MSC	Tyramine	Enzymatic	Research & Therapeutic	[25]
	MSC	Tyramine	Enzymatic	Research & Therapeutic	[32]
Hyaluronic acid	MSC	Fibrinogen added	Thiol-ene click chemistry	Research	[40]
	MSC	Tyramine	Enzymatic	Research & Therapeutic	[32]
Matrigel	RWPE1n)	N/A	Temperature	Research	[36]
Collagen-gelatin	3T3 fibroblasts	N/A	Photopolymerization (riboflavin)	Research	[37]
Poly(ethylene glycol)	MSC	TG & MMP	Enzymatic	Research	[123]
	MSC, bovine chondrocytes	Acrylate	Photopolymerization	Research & Therapeutic	[31]
	CHOo)	RGD peptides	Photopolymerization	Research, Diagnostic & Therapeutic	[131]

^a)Mesenchymal stem cells;

^b)Stromal cell line from bone marrow;

^c)Human umbilical vein endothelial cells;

^d)NIH/Swiss mouse embryonic fibroblast;

^e)Unicellular freshwater cyanobacteria;

^f)Chlamydomonas reinhardtii;

^g)Murine calvarial pre-osteoblasts;

^h)Competitive ligand exchange crosslinking;

ⁱ⁾Colorectal cell line;

^j)Acute lymphoblastic leukemia;

^k)Chronic myelogenous leukemia;

^l)Female human lymphoid cell line;

^m)Male human lymphoid cell line;

ⁿ⁾Human epithelial prostate cell line;

^o)Chinese hamster ovary cells.