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. 2022 Oct 19;13:975320. doi: 10.3389/fphar.2022.975320

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Copyright © 2022 Atteeq.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Withaferin A interactions. Withaferin A interactions with multiple intracellular proteins leads to modulation of cancerous activity of cell. Withaferin A has antagonistic activity with NOTCH-1, VEGFR, and JAK/STAT in cytoplasm. In cell’s nucleus, Withaferin A inhibits activity of transcription factors NF-κB, ER-α, and STAT3; preventing transcription of their downstream products. These interactions inhibit cancerous cell activity marked by cell proliferation, epithelial to mesenchymal transition, angiogenesis, cell proliferation, metastasis, and cell invasion.