Table 4. Comparison of demographics and relevant comorbidities between patients with normal IENFD on skin biopsy and patients with reduced IENFD on skin biopsy.

IEFND: intraepidermal nerve fiber density.

	Normal IENFD (n = 61)	Abnormal IENFD (n = 19)	p-value
Age (years)	32 ± 9	41 ± 13	0.001
Percent female	90%	84%	0.44
%White	87%	95%	0.058
Symptom duration (years)	5 (4, 6)	7 (3, 10)	0.20
Comorbidities
Autoimmune disease (celiac, Hashimoto’s, RA, Sjogren’s)	16%	37%	0.10
Chiari	5%	2%	0.42
Ehlers-Danlos/Jjint hypermobility	31%	11%	0.13
Fibromyalgia	34%	16%	0.16
Migraine	61%	53%	0.60
Raynaud’s	23%	16%	0.75