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. 2022 Nov 2;24(6):114. doi: 10.1208/s12248-022-00759-1

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Fig. 9 — Relationship of log ADA titer and free ADA LBA signal window. The assay signal window is the ratio of the highest free ADA LBA signal (lowest drug level) and lowest free ADA LBA signal (highest drug level) for each sample solution affinity curve. In general, K_D measurements were more accurate and precise for samples with ADA log titers ≥ 3.0 and assay signal window ≥ 4.0