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. 2022 Oct 26;2022:8275574. doi: 10.1155/2022/8275574

Figure 3.

Figure 3

FXR activates DHRS9 and upregulates DHRS9 expression. (a) Venn diagram of FXR target genes predicted by MotifMap and GTRD databases. (b) Scatter chart of the Pearson correlation analysis between FXR and DHRS9 in TCGA database. (c) Boxplot of DHRS9 expression in normal and colon cancer tissues. (d) mRNA expression of DHRS9 in colon cancer cell lines measured by qRT-PCR. (e) Binding sequence of DHRS9 promoter region and FXR in JASPAR database. (f and g) Binding between FXR and DHRS9 promoter region demonstrated by ChIP and dual-luciferase assays. (h and i) Effect of FXR overexpression on DHRS9 expression in HT-29 cells detected by qRT-PCR and Western blot. (∗ denotes P < 0.05).