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. 2022 Oct 26;2022:9313436. doi: 10.1155/2022/9313436

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Copyright © 2022 Man Zhang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Betaine reduces the expression of NLRP3 inflammasome in mice GD brain region. Immunostaining with anti-NLRP3 (green) and anti-Iba1 (microglia activation marker, (red) antibodies, and nuclei stained with DAPI (blue). (a) Representative images of NLRP3 fluorescence intensity after stimulation with LPS. (b) Analysis of NLRP3 fluorescence intensity in brain regions. (c) Analysis of Iba1 fluorescence intensity in brain regions. (d) Colocalization analysis of NLRP3 and Iba1. The results were expressed as mean ± SEM; ^##P < 0.01 and ^###P < 0.001 compared to the normal control group; ^∗P < 0.05 and ^∗∗∗P < 0.001 compared to the model group, n = 6.