Table 1.

Cell type and source

Cell type	Cell source	Functionality	References
Hepatocytes	Primary hepatocytes, from human	Metabolic and secretory functions of the liver	[65, 66]
	HepG2 (hepatocellular carcinoma, cell line, from human)	Metabolic and secretory functions of the liver	[67–70]
	Huh7 (hepatocellular carcinoma, cell line, from human)	Metabolic and secretory functions of the liver	[71, 72]
	HepaRG (hepatic progenitor cells, from human)	Can differentiate into hepatocytes and bile duct cells to achieve liver metabolism and secretion	[73, 74]
	MSCs (mesenchymal stem cells, from human)	Has the potential to differentiate into a variety of cells, it can differentiate into hepatocytes for metabolism and secretion	[75–77]
	hiPSCs (human-induced pluripotent stem cells, from human)	Has the potential to differentiate into a variety of cells, it can differentiate into hepatocytes for metabolism and secretion	[25, 26, 78–80]
Kupffer cells	Primary Kuffer cells, from human	Remove foreign bodies, monitor tumors	[66]
	Kup5, (c-myc-immortalized Kupffer cells, cell line, from mouse)	Remove foreign bodies, monitor tumors	[81]
Stellate cells	LX-2 (hepatic stellate cells, cell line, from human)	Involved in vitamin A metabolism and fat storage, producing extracellular matrix	[82]
Liver perisinusoidal endothelial cell	HUVEC (human umbilical vein endodermal cell, cell line, from human)	Reduce blood flow rate, promote substance interaction	[14, 81, 83]
Cholangiocytes	SV40SM (cholangiocytes, cell line, from mouse)	Formation of bile ducts	[84]
	Cholangiocarcinoma cells, from human	Induced hepatocarcinogenesis	[85]