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. 2022 Oct 10;41(45):4917–4928. doi: 10.1038/s41388-022-02487-4

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Data obtained from The Cancer Proteome Atlas [146]. Cancer types are ranked by phosphorylated Tyr419 (upper panel) and the corresponding total Src abundance is shown in the bottom panel. Data were generated by the TCPA by first normalising protein values across samples, then normalising sample values across proteins, and finally combining data across multiple batches after a replicate-based normalisation (see https://tcpaportal.org/tcpa/faq.html and [146]). The plots were generated with R (v 4.1.2) [147]. The whiskers are the minimum and maximum value within 1.5 times the interquantile range under or over the 25th and 75th percentile respectively, the lower and upper hinges correspond to the first and third quartiles (the 25th and 75th percentiles), the bar corresponds to the median and the outliers are not shown. Adrenocortical carcinoma (ACC, n = 46), Bladder Urothelial Carcinoma (BLCA, n = 344), Breast invasive carcinoma (BRCA, n = 874), Cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC, n = 171), Cholangiocarcinoma (CHOL, n = 30), Colon adenocarcinoma (COAD, n = 357), Lymphoid Neoplasm Diffuse Large B-cell Lymphoma (DLBC, n = 33), Esophageal carcinoma (ESCA, n = 126), Glioblastoma multiforme (GBM, n = 205), Head and Neck squamous cell carcinoma (HNSC, n = 346), Kidney Chromophobe (KICH, n = 63), Kidney renal clear cell carcinoma (KIRC, n = 445), Kidney renal papillary cell carcinoma (KIRP, n = 208), Brain Lower Grade Glioma (LGG, n = 427), Liver hepatocellular carcinoma (LIHC, n = 184), Lung adenocarcinoma (LUAD, n = 362), Lung squamous cell carcinoma (LUSC, n = 325), Mesothelioma (MESO, n = 61), Ovarian serous cystadenocarcinoma (OV, n = 411), Pancreatic adenocarcinoma (PAAD, n = 105), Pheochromocytoma and Paraganglioma (PCPG, n = 80), Prostate adenocarcinoma (PRAD, n = 351), Rectum adenocarcinoma (READ, n = 130), Sarcoma (SARC, n = 221), Skin Cutaneous Melanoma (SKCM, n = 353), Stomach adenocarcinoma (STAD, n = 392), Testicular Germ Cell Tumours (TGCT, n = 118), Thyroid carcinoma (THCA, n = 372), Thymoma (THYM, n = 90), Uterine Corpus Endometrial Carcinoma (UCEC, n = 404), Uterine Carcinosarcoma (UCS, n = 48), Uveal Melanoma (UVM, n = 12).