Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Aug 31;611(7934):139–147. doi: 10.1038/s41586-022-05273-0

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 4 — (a-e) Single cell VDJ analysis of ASCs and memory compartments from ICU-C patients (n = 3) (a,b) BASELINe selection analysis of CDR selection in ASC vs. memory B cell populations, grouped by isotype (n = 4). (b) Statistical selective pressure comparisons of selected isotypes. Bars = 95% CI (c) Frequency of clonotypes whose most expanded member maintains germline heavy and light chain BCR configuration from IgG1⁺ ASC or CD27⁺ memory compartments. (d) Clonotype connectivity between IgG1⁺ ASCs and the contemporaneous CD27⁺ memory compartment. Patients displaying any connectivity highlighted in green. (e) Relative clonal connectivity between mutated (>=1% mutation) versus unmutated (<1%) IgG1⁺ ASCs and the contemporaneous memory. Only two patients showing active connection between the compartments [2d] are evaluated. (c) Statistical significance was determined using paired two-tailed t-testing between indicated groups. *P ≤ 0.05; **P ≤ 0.01.