Extended Data Fig. 5. Severe COVID-19 correlates with increased autoreactivity against multiple autoantigens.

(a, b) HD, OUT-C, and ICU-C patient frozen plasma was tested against a variety of autoantigens in Exagen’s clinical laboratory. (a) Distribution of total positive clinical tests across the HD, OUT-C, and ICU-C cohorts. (b) Linear regression of anti-carbamylated protein titers vs. anti-nuclear antigen titers across the ICU-C cohort. Patients with positive anti-CarP titers are highlighted in red.