Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Oct 5;611(7934):105–114. doi: 10.1038/s41586-022-05288-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 8 — a. Frequencies of trinucleotides around germline NUMTs breakpoints. The breakpoints of nuclear genome are shown at the top and mtDNA genomes at the bottom, common&rare, ultra-rare NUMTs and the expected frequencies shown in the different colours. Trinucleotides of breakpoint flanks more likely occurred in nCC/CCn on mtDNA genome and less likely in nTT/TT on both nuclear and mtDNA genomes, particularly for ultra-rare NUMTs. The same trend was not seen in the tumour-specific NUMTs (b), indicating the signal is driven by biology, but not the sequencing artefacts. b. Frequencies of trinucleotides around tumour-specific NUMTs breakpoints in the nuclear genome (top) and mtDNA genomes (bottom), tumour-specific NUMTs and the expected frequencies shown in the different colours. P values # < 0.1, * < 0.05, < 0.01 **, < 0.001 ***, < 0.0001 **** (two-sided Fisher’s exact test) (Supplementary Table 6). c. Distribution of the distance between PRDM9 binding sites and tumour-specific NUMTs within each tumour type. d. Age of NUMTs estimated in this study. Y axis shows the frequencies of NUMTs in African and non-African populations. The frequencies of NUMTs were different between African and non-African, particularly for the older NUMTs which were more common seen in African population.