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. 2022 Oct 5;611(7934):105–114. doi: 10.1038/s41586-022-05288-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, Nuclear genotypes at common single nucleotide polymorphisms (SNPs) projected onto two leading principal components (PC1 and PC2). Individuals are coloured according to the assigned ancestry of their nuclear genome. The pie chart shows the proportion of each group overall: East Asian (cyan), South Asian (pink), African (green), American (red), European (blue) and unassigned (yellow). b, The average number of NUMTs detected in populations with different ancestries. Vertical lines show the average number of NUMTs from each population. c, Heat map showing P values from pairwise comparison of the average number of NUMTs detected between populations of different ancestries (two-sided Wilcoxon rank-sum test). d, Chromosomal locations of NUMT insertions detected in this study, coloured by the frequency of NUMTs. Dots show the locations of the NUMTs. Chromosomal locations of different NUMT insertions detected for each ancestry are shown in Extended Data Fig. 2.