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. 2022 Oct 5;611(7934):105–114. doi: 10.1038/s41586-022-05288-7

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, Average number of NUMTs detected per normal and tumour sample that are not present in the reference sequence. b, Average number of tumour-specific NUMTs detected in tumours. c, Tumour-specific NUMTs detected in 12,509 normal–tumour pairs. Left, NUMT size and location on mtDNA. Links connect breakpoints between mtDNA and nuclear genomes. d, Size distribution of tumour-specific NUMTs (red) and tumour-specific NUMTs smaller than 1,000 bp (orange). e, Size distribution of all germline and tumour-specific NUMTs (top) and germline and tumour-specific NUMTs smaller than 1,000 bp (bottom). f, The percentage of different types of tumours with at least one tumour-specific NUMT. g, P values from pairwise comparison of the average number of tumour-specific NUMTs from different tumour types. h, Average number of tumour-specific NUMTs for each tumour type. Data are mean ± s.e.m. Glioma, n = 359; bladder, n = 268; breast, n = 2,038; CUP, n = 52; childhood, n = 170; colorectal, n = 1,934; endometrial, n = 579; HAEMONC, n = 72; HPB, n = 258; lung, n = 1,061; melanoma, n = 244; OPC, n = 151; ovarian, n = 423; prostate, n = 298; renal, n = 1,022; sarcoma, n = 979; TGCTs, n = 47; UGI, n = 184. i, Chromosomal locations of tumour-specific NUMTs, shown as red bars. j, NUMTs involved in FUS–DDIT3 chimeric fusion. NUMTs are shown as a blue link and the FUS–DDIT3 fusion is shown as a green link. The chromosome number and mitochondrial genome are indicated. k, Example of lost NUMTs in a breast tumour sample. The links represent NUMTs detected in either normal (left) or tumour (right) samples. The chromosome number and mitochondrial genome are indicated. CUP, carcinoma of unknown primary; endometrial, endometrial carcinoma; glioma, adult glioma; HAEMONC, haemato-oncology; HPB, hepato-pancreato-biliary cancer; melanoma, malignant melanoma; OPC, oral and oropharyngeal cancers; TGCTs, testicular germ cell tumours; UGI, upper gastrointestinal cancer.