Skip to main content
. 2022 Aug;23(8):1097–1108. doi: 10.1016/S1470-2045(22)00334-5

Figure 2.

Figure 2

Network plots for risk of CIN treatment failure (A) and preterm birth (B)

The width of each line connecting two treatments is proportional to the inverse standard error of the fixed-effect summary effect size for these two treatments (number of studies for each pairwise meta-analysis is also shown). The diameter of each node is proportional to the number of women included in this group. As shown in part A, the network for treatment failure included a total of 19 240 women across 71 studies: CKC (34 studies; n=3865); laser conisation (19 studies; n=2473); LLETZ (43 studies; n=5644); radical diathermy (four studies; n=277); laser ablation (26 studies; n=3539); cold coagulation (six studies; n=667); and cryotherapy (18 studies; n=2775). As shown in part B, the network for preterm birth included a total of 68 817 women across 29 studies: CKC (14 studies; n=2598); laser conisation (nine studies; n=3799); LLETZ (25 studies; n=19 593); radical diathermy (one study; n=760); laser ablation (seven studies; n=1586); cold coagulation (one study; n=56); cryotherapy (three studies; n=67); and COLPO (ten studies; n=40 358). CIN=cervical intraepithelial neoplasia. CKC=cold knife conisation. COLPO=untreated colposcopy group. LLETZ=large loop excision of the transformation zone.