Figure 2.

Geometric mean dolutegravir plasma concentration time curves

(A) Children receiving dolutegravir 25 mg dispersible tablet once daily (n=1, black solid line) or twice daily with rifampicin (n=1, grey line). (B) Children receiving dolutegravir 25 mg film-coated tablet once daily (n=5, black solid line) or twice daily with rifampicin (n=5, grey line). (C) Children receiving dolutegravir 50 mg film-coated tablet once daily (n=7, black solid line) or twice daily with rifampicin (n=7, grey line). Solid lines in the twice-daily curves indicate observed concentrations; grey dotted lines indicate imputed values by repeating the first 12 h. Geometric mean dolutegravir plasma concentration time curves with adult reference parameters of maximum plasma concentration (C_max) in adults receiving dolutegravir 50 mg twice daily (blue dotted line), trough plasma concentration (C_trough) in adults receiving dolutegravir 50 mg once daily (green dotted line), and dolutegravir 90% effective concentration (EC₉₀) in the adult dolutegravir 10-day monotherapy study (Min and colleagues, 2011;²⁰ red dotted line).