Table 2.
Patients’ comorbidities at the time of type 2 diabetes diagnosis by age groups in the UK and US cohorts
| Variable | Age at type 2 diabetes diagnosis (years) | Overall | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 18–39 | 40–49 | 50–59 | 60–69 | 70–79 | ||||||||
| UK | USA | UK | USA | UK | USA | UK | USA | UK | USA | UK | USA | |
| n (%) | 18,809 (8) | 84,851 (7) | 37,157 (16) | 146,953 (13) | 59,105 (26) | 281,957 (25) | 66,573 (29) | 321,114 (28) | 49,288 (21) | 308,247 (27) | 230,932 | 1,143,122 |
| Any mental illness | 8016 (43) | 31,351 (37) | 17,989 (48) | 57,593 (39) | 29,280 (50) | 105,282 (37) | 32,561 (49) | 105,136 (33) | 22,673 (46) | 81,505 (26) | 110,519 (48) | 380,867 (33) |
| Depression | 6063 (32) | 22,300 (26) | 13,902 (37) | 41,940 (29) | 21,891 (37) | 79,277 (28) | 23,081 (35) | 80,868 (25) | 15,993 (32) | 63,557 (21) | 80,930 (35) | 287,942 (25) |
| ASCVD | 282 (1) | 2289 (3) | 1993 (5) | 9541 (6) | 7095 (12) | 35,341 (13) | 14,506 (22) | 63,381 (20) | 16,012 (32) | 88,177 (29) | 39,888 (17) | 198,729 (17) |
| Any cardiovascular disease | 314 (2) | 2914 (3) | 2132 (6) | 11,270 (8) | 7404 (13) | 39,499 (14) | 15,120 (23) | 69,355 (22) | 16,823 (34) | 97,321 (32) | 41,793 (18) | 220,359 (19) |
| Chronic kidney disease | 608 (3) | 4094 (5) | 2534 (7) | 12,782 (9) | 7661 (13) | 35,952 (13) | 16,736 (25) | 65,342 (20) | 21,832 (44) | 97,745 (32) | 49,371 (21) | 215,915 (19) |
| Microvascular disease | 897 (5) | 11,703 (14) | 3304 (9) | 30,694 (21) | 9163 (16) | 69,947 (25) | 18,560 (28) | 96,429 (30) | 22,971 (47) | 120,113 (39) | 54,895 (24) | 328,886 (29) |
| Cancer | 268 (1) | 1457 (2) | 894 (2) | 4340 (3) | 2702 (5) | 12,741 (5) | 5844 (9) | 23,284 (7) | 6759 (14) | 34,045 (11) | 16,467 (7) | 75,867 (7) |
| Hypertension | 4154 (22) | 34,839 (41) | 15,296 (41) | 88,576 (60) | 34,248 (58) | 201,483 (71) | 47,404 (71) | 253,567 (79) | 39,787 (81) | 258,058 (84) | 140,889 (61) | 836,523 (73) |
| Dyslipidaemia | 1439 (8) | 23,425 (28) | 7450 (20) | 71,091 (48) | 20,745 (35) | 171,362 (61) | 33,887 (51) | 223,374 (70) | 29,410 (60) | 222,991 (72) | 92,931 (40) | 712,243 (62) |
| Comorbidity | 6805 (36) | 49,782 (59) | 15,379 (41) | 88,135 (60) | 27,538 (47) | 168,354 (60) | 37,488 (56) | 198,467 (62) | 34,356 (70) | 201,108 (65) | 121,566 (53) | 705,846 (62) |
Date are presented as n (%)
Any cardiovascular disease includes ASCVD + heart failure
Cancer cases involve all malignant cancer excluding skin cancer
Microvascular diseases include retinopathy, neuropathy and nephropathy including chronic kidney disease
Comorbidity comprises at least one of cardiovascular disease, cancer, microvascular disease and obesity grade 2+
ASCVD, atherosclerosis cardiovascular disease