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. 2022 Sep 16;65(12):2132–2145. doi: 10.1007/s00125-022-05789-0

Table 2.

Correlation between total hepatic lipid accumulation and metabolic/inflammatory variables in 12-month-old mouse offspring

Variable Male offspring Female offspring
r p n r p n
BW (g) 0.8982 <0.001 31 0.6605 <0.001 34
VAT (g) 0.9101 <0.001 30 0.6726 <0.001 34
Insulin (pmol/l) 0.6957 <0.001 28 0.3376 0.0633 31
Leptin (ng/ml) 0.9212 <0.001 30 0.6305 <0.001 33
Adgre1 0.9018 <0.001 30 0.2581 0.1405 34
Ccl2 0.8549 <0.001 30 0.4835 0.0044 33
Itgax 0.9159 <0.001 30 0.4255 0.0152 32
Tnf 0.8827 <0.001 31 0.342 0.0514 33

Correlation was assessed using two-tailed Spearman correlation between total hepatic lipid content (measured using Folch assay) with the following variables: body weight at post mortem, weight of collected VAT (sum of gonadal, intraperitoneal and retroperitoneal depots), serum insulin levels, serum leptin levels and expression of Adgre1, Itgax, Ccl2 and Tnf in gonadal adipose tissue relative to Con offspring

BW, body weight; VAT, visceral adipose tissue