Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 2;13:6570. doi: 10.1038/s41467-022-34264-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a Number of protein-coding genes on chrX. Genes associated with at least one monogenic disorder: orange, confirmed genes; blue: genes with provisional associations (P), associated with susceptibility factors to multifactorial disorders (M) or traits (T) (altogether: PMTs); grey: genes without known phenotypes (no-disorder genes). b Number of protein-coding genes per chromosome. Dark and light colors represent genes with Clinical Synopsis (CS) data for at least one of the associated phenotypes (+CS) or without CS (-CS), respectively. c Per chromosome enrichment/depletion of protein-coding genes with at least one associated phenotype comprising Clinical Synopsis data (confirmed CS-genes). d Fraction of confirmed CS-genes among protein-coding genes. e–n. Predominance of chrX genes associated with neurologic features. e, g, i, k and m, Per chromosome enrichment/depletion of genes with non-specific neurologic features (e), intellectual disability (g), seizures (i), language impairment (k), or motor development (m). f, h, j, l and n, Fraction of genes associated with non-specific neurologic features (f), intellectual disability (h), seizures (j), language impairment (l), or motor development (n). c–n, Yellow, enrichment; dark-grey, depletion; light grey, not significant (ns). Terms corresponding to the same neurological clinical features were used in OMIM searches (Supplementary Data 3). Only significant p-values are shown (Fisher’s test (two-sided) followed by Bonferroni correction for multiple testing across both chromosomes and phenotypes). a–n Source data are provided as a Source Data file.