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. 2022 Nov 2;13:6570. doi: 10.1038/s41467-022-34264-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a Overview of the approach used to uncover features shared by disorder genes (details in Methods). Density plots showing the distribution of LOEUF (b), misZ (c) and exon-conservation score (d) according to gene group. Confirmed disorder genes (orange), PMT genes (blue), no-disorder genes (grey). Vertical dashed lines separate deciles of the overall distribution. Grey areas depict deciles for which confirmed disorder-associated genes are enriched (related to Supplementary Fig. 2). e Euler diagrams showing the number of genes fulfilling LOEUF (L), misZ (M) and exon-conservation (E) criteria for confirmed (left), PMT (middle) and no-disorder genes (right). Thresholds: LOEUF ≤ 0.326, misZ ≥ 2.16, exon-conservation score ≥ 0.9491. Genes fulfilling at least two LME criteria are shown in green (light or dark green for two or three criteria, respectively). Genes meeting only one of the metrics are shown in different shades of grey (dark to light: LOEUF, misZ, exon-conservation). Genes not meeting LME criteria are shown in white. b–e, Source data are provided as a Source Data file.