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. 2022 Nov 2;13:6570. doi: 10.1038/s41467-022-34264-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Sources of data reinforcing predicted genes as putative disorder-associated included variant or expert curated NDD gene databases, literature and exome data examination from two additional cohorts of patients with developmental disorders. Known point mutations in no-disorder genes. Boxplot showing the number of known mutations reported in HGMD and DECIPHER (b) or their value normalized by coding-sequence (CDS) length (c) according to their predicted status. Box plot elements are defined as follows: center line: median; box limits: upper and lower quartiles; whiskers: 1.5× interquartile range; points: outliers. d Percentage of each class of no-disorder genes present in the expert curated NDD gene databases. Number of genes are shown in brackets. b–d White, non-predicted no-disorder genes; purple, predicted no-disorder genes. Source data are provided as a Source Data file. e ML-predicted genes present in expert curated NDD gene databases. Genes in SysNDD are classified as D (definite NDD gene) or L (limited evidence as NDD gene). Data underlying this scheme can be found in Supplementary Data 8.