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. 2022 Nov 2;12:18529. doi: 10.1038/s41598-022-23304-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Viability of fibroblasts seeded on scaffold and TCPS as control during the 14 days, (B) SEM images of fibroblasts on the surface of the PU-CA scaffold 3 days after cell culture. (C) DAPI staining after culture of cells on days 7 and 14. (D) VEGF, DDR2, and SGPL1 gene expression at mRNA level. Three days after cell seeding on scaffold and TCPS the cells of each group were tested by Real-Time PCR. Manipulated cells showed more expression in certain genes compared to Hu02 and TCPS groups. (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001).