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. 2022 Nov 2;12:18529. doi: 10.1038/s41598-022-23304-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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H&E stained microscopic sections of wounded tissue on different days after surgery for Ctrl, Sca, Sca + Hu02, and Sca + Manipulated Hu02 groups. (A1)–(A4): Day 2 after surgery. (A1) and (A2): Tissue necrosis with high neutrophil infiltration (black arrow) and no angiogenesis. (A3): Tissue necrosis with high neutrophil infiltration (black arrow) and with mild angiogenesis as few formation of new blood vessels (arrow head). (A4): Tissue necrosis with mild neutrophil infiltration (black arrow) and remarkable angiogenesis (arrow head). (B1)–(B4): Day 5 after surgery. (B1) and (B2): Tissue necrosis with neutrophil infiltration (black arrow), mild angiogenesis (arrow head), mild fibroproliferation, and new connective tissue formation (yellow arrow). (B3): Tissue necrosis with neutrophil infiltration (black arrow), moderate angiogenesis (arrow head), hemorrhage (black star), high fibroproliferation, and new connective tissue formation (yellow arrow). (B4): Remarkable angiogenesis (arrow head), moderate fibroproliferation (yellow arrow), and new connective tissue formation and collagen deposition (green stars). (C1)–(C4): Day 12 after surgery. (C1): Reepithelialization (yellow star) and increased connective tissue. (C2): Reepithelialization (yellow star), increased connective tissue, and some area of hemorrhage (black star). (C3): Reepithelialization (yellow star) and increased connective tissue. (C4): Reepithelialization (yellow star), increased connective tissue, and some area of hemorrhage (black star). Granulation tissue and angiogenesis (arrow head) were present in some areas. (D1)–(D4): Day15 after surgery. (D1): Reduction of fibroproliferation. (D2): Reduction of fibroproliferation and the presence of subepidemal hemorrhage (black star) in some area. (D3): Reduction of fibroproliferation and beginning of scar tissue formation (red star). (D4): Reduction of fibroproliferation and remarkable scar tissue formation as large parallel bundles (red star).