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. 2022 Oct 20;13:1005045. doi: 10.3389/fimmu.2022.1005045

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Copyright © 2022 Rahmy, Mishra, Murphy, Blagg and Lu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NDNB1182 enhanced ICB therapy in the PyMT-7160 syngeneic mammary tumor model. (A) Growth curves of PyMT-7160 tumors treated with vehicle control (N=8), NDNB1182 (50mg/kg, i.p. daily; N=10), ICB (anti-PD1 plus anti-CTLA4, 10mg/kg, i.p., twice/week; N=10), or concurrent NDNB1182 plus ICB (N=8). (B, C) Quantification results and gating strategy for tumor-infiltrating CD8⁺ T cells in treated PyMT-7160 tumors. (D, E) Quantification results and gating strategy for tumor-infiltrating CD11c⁺ MHC-II⁺ dendritic cells (DCs) in treated PyMT-7160 tumors. (F) qRT-PCR result of Ifit1/2/3 and two ERV elements for PyMT-7160 tumors treated with DMSO, NDNB1182, ICB, or NDNB1182 plus ICB (N=3/group).In (A, B, D, F), data represent mean ± SEM. #P>0.05; *P<0.05, **P<0.01, ****P<0.0001, Student’s t-test. In (A, B, D), one-way ANOVA test result was shown in red (*P<0.05, **P<0.01, ***P<0.001).