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. 2022 Nov 2;12:18439. doi: 10.1038/s41598-022-21891-0

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Represented the ratios (a), median fluorescence intensity (b) and adjusted expression (c) of C5AR1, CLEC4A and NLRP3 proteins on CD3⁺ lymphocytes between non-malignant pulmonary diseases (n = 10) and early-stage NSCLC patients (n = 63). Median fluorescence intensity of CD3⁺NLRP3⁺ in early-stage NSCLC patients was 1585 [range 478–5224] which was higher than non-malignant pulmonary diseases, 899 [range 354–1888, p = 0.01]. The limited number of patients with non-malignant pulmonary disease in our study impacted the ability to show if PBMCs protein expression as a biomarker could discriminate between these conditions.