Table 3.
Concentrations of cytokines and chemokines in the cortex culture media in control and High A4 in trial 1
| Group | ||||
| Control | High A4 | SEM | P-value | |
| n | 11 | 9 | ||
| Cytokine/chemokine, pg/mL | ||||
| ANG-1 | 56.03 | 64.76 | 26.96 | 0.83 |
| CD40 ligand | 3624.31 | 1103.59 | 261.58 | 0.19 |
| CCL4/MIP-1β | 371.74 | 616.61 | 138.60 | 0.25 |
| CCL5/RANTES | 2198.06 | 2800.50 | 1058.11 | 0.70 |
| CXCL9 | 0.16 | 90.43 | 45.45 | 0.19 |
| CXCL10 | 1121.92 | 2179.34 | 378.69 | 0.07† |
| Decorin | 2104.51 | 2274.92 | 383.00 | 0.77 |
| INF-α | 104.81 | 227.51 | 30.58 | 0.01** |
| INF-β1 | 544.81 | 710.25 | 167.25 | 0.51 |
| INF-γ | 7.40 | 15.69 | 3.21 | 0.10† |
| IL-1α | 30.56 | 55.49 | 10.26 | 0.12 |
| IL-1β | 18.93 | 17.60 | 9.15 | 0.92 |
| IL-10 | 13 399 | 10 854 | 5700.58 | 0.76 |
| IL-13 | 5.34 | 26.13 | 5.18 | 0.01** |
| IL-17A | 54.19 | 36.50 | 27.19 | 0.66 |
| IL-18 | 464.97 | 713.38 | 334.88 | 0.62 |
| IL-21 | 31.05 | 38.41 | 14.83 | 0.74 |
| IL36RA/IL-1F5 | 1.08 | 2.72 | 0.73 | 0.15 |
| TNFα | 22.78 | 95.66 | 14.88 | 0.001*** |
| LIF | 28 110 | 54 877 | 15 232 | 0.25 |
* P-value <0.05.
** P-value <0.01.
*** P-value < 0.001.
† P-value <0.10.
MIG = monokine induced by gamma interferon, IP-10 = interleukin protein 10, IFN-α = interferon alpha, IL-1α = interleukin 1 alpha, IL-1β = interleukin 1 beta, IL-17A = Interleukin-17A.