Table 1.
Marker ID | Chr | Position (hg19) | Alleles (risk/non-risk)b | TDMA Direction | Meta-analysis P-values | Meta-analysis Odds ratios | Risk allele frequenciesa | Nearby genes | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Psoriasis | CAD | TDMA | Psoriasis | CAD | TDMA | Psoriasis | CAD | ||||||
rs6430076 | 2 | 145797185 | G/A | Opposing | 8.2 × 10−5 | 1.8 × 10−6 | 1.6 × 10−8 | 0.92 | 1.05 | 1.07 | 0.35 | 0.32 | TEX41, ZEB2 |
rs1990760 | 2 | 163124051 | T/C | Shared | 5.7 × 10−15 | 5.3 × 10−5 | 1.3 × 10−18 | 1.16 | 1.04 | 1.10 | 0.61 | 0.56 | IFIH1 |
rs76151170 | 12 | 56659320 | C/T | Shared | 9.8 × 10−16 | 6.0 × 10−5 | 2.8 × 10−19 | 1.38 | 1.09 | 1.23 | 0.94 | 0.94 | IL23A. COQ10A |
rs12979495 | 19 | 10964632 | G/A | Shared | 1.3 × 10−5 | 4.7 × 10−10 | 2.5 × 10−11 | 1.10 | 1.07 | 1.08 | 0.74 | 0.75 | DNM2, ILF3 |
Chr chromosome, OR odds ratio, p p-value, CAD coronary artery disease.
aAllele frequencies are provided for each entire meta-analysis (cases and controls), rather than specifically for each disease.
bRisk allele corresponds to TDMA. Gene names are italicized.