Table 2.

Results for Mendelian randomization

	Num. markers	Psoriasis								CAD
		IVW		Median		Mode		MR-RAPS		IVW		Median		Mode		MR-RAPS
		OR	P	OR	P	OR	P	OR	P	OR	P	OR	P	OR	P	OR	P
Psoriasis	184	—	—	—	—	—	—	—	—	1.01	0.14	1.00	0.64	1.00	0.91	1.01	0.09
CAD	448	1.14	6.3 × 10−4	1.16	3.6 × 10−3	1.45	0.02	1.13	2.2 × 10−3	—	—	—	—	—	—	—	—
BMI	969	1.48	1.5 × 10−9	1.38	1.0 × 10−3	1.96	0.08	1.50	2.2 × 10−9	1.51	5.1 × 10−71	1.52	1.6 × 10−61	1.45	2.8 × 10−4	1.51	1.6 × 10−69
WHR	796	1.53	1.0 × 10−6	1.49	4.4 × 10−4	1.12	0.78	1.52	3.1 × 10−6	1.56	4.5 × 10−50	1.60	5.9 × 10−47	1.23	0.21	1.57	3.6 × 10−50
T2D	561	1.05	0.08	1.07	0.08	0.86	0.29	1.06	0.06	1.16	1.1 × 10−41	1.18	1.4 × 10−45	1.16	4.3 × 10−4	1.16	3.3 × 10−39
HDL	362	1.04	0.44	0.92	0.35	1.23	0.21	1.06	0.27	0.87	6.1 × 10−9	0.87	1.5 × 10−8	0.89	0.17	0.88	9.6 × 10−11
LDL	301	1.04	0.43	0.98	0.78	0.86	0.29	1.02	0.67	1.31	7.2 × 10−35	1.19	2.3 × 10−13	1.11	0.19	1.44	3.4 × 10−211
TC	308	1.12	0.03	1.03	0.63	0.97	0.85	1.12	0.04	1.38	7.4 × 10−41	1.22	3.9 × 10−16	1.43	8.6 × 10−4	1.48	1.4 × 10−222
TG	353	1.07	0.16	1.01	0.87	0.84	0.34	1.06	0.22	1.21	3.6 × 10−20	1.16	2.7 × 10−10	1.15	0.02	1.21	5.8 × 10−24

Results significant after Bonferroni adjustment are indicated in bold.

IVW inverse-variance weighted, Num. number of, CAD coronary artery disease, BMI body mass index, WHR waist-hip ratio, T2D type 2 diabetes, HDL high-density lipoprotein, LDL low-density lipoprotein, TC total cholesterol, TG triglycerides, OR odds ratio, p p-value.