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Overview of specific steps in mitophagy that are perturbed in neurodegenerative disease. Mitophagy progression is altered at different stages of the process. Disruptions occur during the initial recognition of damaged mitochondria, formation and transport of mitophagosomes, and degradation of mitochondria by lysosomes. The particular point(s) of mitophagy defect vary with neurodegenerative disease, and, possibly with, disease subtype. Created with BioRender.com.
