Table 2.
Summary of somatic differences between East Asian (EAS) and White ancestries
| Study | Data sourcea | Subtype | #Total | #EAS | Comparisonb | EAS enriched | White enriched | Shared pattern |
|---|---|---|---|---|---|---|---|---|
| Koo (2020) | South Korea | GBM | 340 | 90 | TCGA | MAPK and p53 pathways | / | / |
| Chan (2016) | China | LGG | 459 | 459 | TCGA | Triple-negative gliomas | / | / |
| Zeng (2021) | China | HGG+LGG | 83 | 83 | MSKCC | H3F3A mutation, MET amplification | TERT mutation, EGFR, and CDKN2A/B CNV | / |
| Hu (2018) | China & South Korea | sGBM | 188 | 108 | TCGA | / | Hypermutation | / |
| Lassman (2019) | China, Singapore, South Korea | GBM | 3150 | 484 | Enrolled White | / | EGFR amplification | / |
| Suzuki (2015) | Japan | LGG | 760 | 335 | TCGA | SETD2 somatic mutation | / | Three-fourths IDH1 mutation |
aCountry where the samples were collected.
bPopulation compared with East Asians.
Note: LGG, lower grade glioma; HGG, high-grade glioma; sGBM, secondary GBM