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. 2022 Oct 20;13:1042511. doi: 10.3389/fendo.2022.1042511

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Copyright © 2022 Wang, Zhang, Jiang, Zhao, Xu, Zeng, Xu and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental Procedure. NOD mice were divided into the control group, the experimental autoimmune thyroiditis (EAT) group and the Allo-aca treatment group. The EAT model was replicated by 0.05% iodine water intaking for 8 weeks. The Allo-aca treatment group received a subcutaneous injection of Allo-aca daily. The peripheral blood, thyroid and spleen of the experimental animals were used in the subsequent experiments.