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. 2022 Oct 20;13:1042511. doi: 10.3389/fendo.2022.1042511

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Copyright © 2022 Wang, Zhang, Jiang, Zhao, Xu, Zeng, Xu and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Allo-aca alleviates autoimmune thyroiditis caused by high iodine intake. (A) In normal mouse thyroid, the follicles were distributed evenly and there were no infiltrated inflammatory cells. High iodine intake caused autoimmune thyroiditis (EAT) in NOD mice, which was characterized by structural damage to thyroid follicles. Whereas treatment with Allo-aca attenuated the destruction of thyroid follicular cells. (B) Allo-aca significantly reduced the number of lymphocytes in the thyroid gland according to the lymphocyte infiltration score. (C) The body weight of mice was continuously monitored during the experimental period, and there was no statistical difference in body weight among the three groups. n = 4, data are expressed as mean ± standard deviation, **P < 0.01, ***P < 0.001.