TABLE 3.

Linear model

B-cell variable	Clinical variable	Independent variables per model				q-value of clinical variable
		Term	Estimate	se	p-value
CD27+IgA+ memory B-cells	AX	AX	0.886	0.167	<0.001	<0.001
		Age	0.034	0.016	0.039
		Regular OCS	2.001	0.624	0.002
		(Intercept)	1.358	0.869
CD27+IgA+ memory B-cells	R5−R20	R5−R20	9.117	2.240	<0.001	0.002
		Age	0.031	0.017	0.066
		Regular OCS	2.156	0.627	0.001
		(Intercept)	1.307	0.896
CD27+IgA+ memory B-cells	FEF25–75% (z-score)	FEF25–75% (z-score)	−0.683	0.225	0.003	0.026
		Age	0.046	0.019	0.020
		Regular OCS	2.154	0.713	0.003
		(Intercept)	0.764	1.097
CD27+IgA+ memory B-cells	FEV1 (z-score)	FEV1 (z-score)	−0.541	0.177	0.003	0.026
		Age	0.049	0.017	0.005
		Regular OCS	2.137	0.663	0.002
		(Intercept)	0.902	0.940
CD27+IgA+ memory B-cells	FEV1/FVC (z-score)	FEV1/FVC (z-score)	−0.597	0.192	0.002	0.026
		Age	0.044	0.017	0.010
		Regular OCS	2.279	0.649	0.001
		(Intercept)	0.815	0.944
CD27−IgA+ memory B-cells	Number of severe exacerbations	Number of severe exacerbations	0.223	0.068	0.001	0.026
		Age	0.0003	0.011	0.975
		Regular OCS	0.613	0.475	0.199
		(Intercept)	2.097	0.591
CD27−IgA+ memory B-cells	AX	AX	0.339	0.111	0.003	0.026
		Age	−0.003	0.011	0.803
		Regular OCS	0.997	0.415	0.017
		(Intercept)	2.173	0.578
CD27−IgA+ memory B-cells	R5−R20	R5−R20	4.224	1.448	0.004	0.032
		Age	−0.004	0.011	0.718
		Regular OCS	1.152	0.406	0.005
		(Intercept)	2.084	0.579

Linear model describing B-cell subpopulations as a function of clinical characteristics with oral corticosteroids (OCS) and age as confounders. Coefficient estimate, standard error and p-value are given for each term in the model. p-values for the clinical variables were corrected for multiple tests (q-value) and all significant results are shown (q<0.05). AX: reactance area; R5–R20: resistance at 5 Hz−resistance at 20 Hz; FEF_25–75%: forced expiratory flow at 25–75% of FVC; FEV₁: forced expiratory volume in 1 s; FVC: forced vital capacity.