Table 1.

Research questions.

ID	Question	Reason
RQ1	What is the temporal and geographical distribution of the research?	Understand how documents develop over time and how they are distributed among countries interested in genome editing, specifically on deep learning/machine learning techniques to predict CRISPR/Cas9 sgRNA target cleavage
RQ2	Which stakeholders do the documents refer to?	Identify specific stakeholders interested in this research
RQ3	What are the ML models of interest?	Discern the themes that stimulate researchers, listing the use of the most used models. Identify possible techniques that are considered to be most effective by researchers.
RQ4	What are the most frequent research objectives?	Understand the objectives to which the researchers aim, in particular with reference to the target on/off.
RQ5	What types of cells are used in the studies?	Identify the datasets used in the documents, to understand the species involved and the availability of the data.
RQ6	What results are presented in the papers supporting the research?	Understand if the solutions developed by the researchers are working and if they are freely offered to research.
RQ7	Financing?	Investigate which lenders are most interested in this type of research, which indirectly also helps to identify any stakeholders.